{"id":29,"date":"2021-07-24T17:59:57","date_gmt":"2021-07-24T17:59:57","guid":{"rendered":"https:\/\/adjuvants.com\/?post_type=product&#038;p=29"},"modified":"2025-04-30T23:22:21","modified_gmt":"2025-04-30T23:22:21","slug":"alt4","status":"publish","type":"product","link":"https:\/\/adjuvants.com\/?product=alt4","title":{"rendered":"AlT4\u2122"},"content":{"rendered":"<p>AlT4\u2122 is an alum-adsorbed TLR4 agonist. Together they enhance immune responses to antigens and skew to a T&lt;sub&gt;H&lt;\/sub&gt;1 profile. Each 0.5 mL vial of AlT4\u2122 contains 0.5 mL with 1 mg alhydrogel and 125 \u03bcg of TLR4 agonist.<\/p>\n","protected":false},"excerpt":{"rendered":"<h4>AlT4\u2122<br \/>\nTLR4 on Alum<\/h4>\n<p>The TLR4 agonist is absorbed onto aluminum hydroxide (alum) particles. \u00a0These alum particles consist of nanometer crystals that assemble into aggregates of several micrometers and provide a stable particulate formulation for the sustained release of adjuvant. \u00a0In vivo data indicate that TLR4-alum directs the quality of the immune response to a balanced Th1\/Th2 response, whereas alum alone induces a strict Th2 response. \u00a0The product potential of a TLR4-alum formulation is very promising given that the FDA approved GSK\u2019s cervical cancer vaccine Cervarix\u00ae containing a very similar MPL-alum adjuvant formulation.<\/p>\n<hr \/>\n<p><strong>Sold in a vial of 000 mil.<br \/>\n<\/strong>Research-grade only.<\/p>\n<p><a href=\"Darrick.carter@pailifesciences.com\"><strong>Contact us for a Quote for Bulk Orders<\/strong><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":6028,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[16],"product_tag":[],"class_list":{"0":"post-29","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-tlr4-agonists","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AlT4\u2122 - Adjuvants.com<\/title>\n<meta name=\"description\" content=\"AlT4\u2122 is an alum-adsorbed TLR4 agonist. Together they enhance immune responses to antigens and skew to a TH1 profile. Each 0.5 mL vial of AlT4\u2122 contains 0.5 mL with 1 mg alhydrogel and 125 \u03bcg of TLR4 agonist.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adjuvants.com\/?product=alt4\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AlT4\u2122 - Adjuvants.com\" \/>\n<meta property=\"og:description\" content=\"AlT4\u2122 is an alum-adsorbed TLR4 agonist. Together they enhance immune responses to antigens and skew to a TH1 profile. 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