MiT4™
TLR4 in an aqueous buffer
The TLR4 agonist is mixed with a surfactant in solvent and then hydrated in a buffer producing stably suspended micelles. These can be used directly as a “pure” TLR4 agonist with little agonism of other cellular pathways. Adjuvants like this work well given intradermally.
Sold in a vial of 0.5 mL.
Research-grade only. Inquire about cGMP product.
$150.00
Note: This information is also available on the Downloadable Product Sheet
Initial Details
Adjuvant Name: MiT4
Chemical Nature: Other-Micellar Aqueous Suspension
Primary Receptor: TLR
Secondary Receptor: TLR4
Mechanism of Action: TLR4 agonist
Immune Profile Induced: Th1-based
Drug Master File: No
NIAID Support: No
Stability Information: At least 3 months
Storage Information 2-8 degrees C
In Vivo Use (Preclinical)
Is there an associated publication? No
Disease Area/Pathogen: Virus
Parent Organism: Severe acute respiratory syndrome-related coronavirus
Antigen: Recombinant protein
Immunization Route: IM
Readout: Immunogenicity (serology)
Host Species: Mouse-B16
Were PK/Toxicology studies conducted? No
Product Grade and Formulation(s)
Product Grade: Research-grade only
Bedside mixing with antigen possible? Yes
Also used in combination adjuvant-formulation? EmT4
Clinical
Not evaluated in humans yet
Recently Viewed Items
You haven't viewed at any of the products yet.