EmT4™
TLR4 in an oil-in-water emulsion
Oil-in-water (o/w) emulsions consist of metabolizable oils emulsified with biocompatible surfactants in an aqueous bulk phase. Emulsion droplets are ~100 nm in diameter and are stable for years. As an amphiphilic molecule, our TLR4 agonists localize at the oil/water interface. The proposed emulsion formulation is similar to formulations already approved in other vaccines, MF59 and AS03 but with the addition of the TLR4 agonist most resembles emulsions like AS02A or GLA-SE.
Sold in a vial of 0.5 mL.
Research-grade only.
$225.00
This information is also available on the Downloadable Product Sheet
Initial Details
Adjuvant Name: EmT4
Chemical Nature: Emulsion
Primary Receptor: TLR
Secondary Receptor: TLR4
Mechanism of Action: Equalene emulsion plus TLR4
Immune Profile Induced: Mixed Th1/Th2
Drug Master File: No
NIAID Support: Yes
Stability Information: At least 3 months at 2-8 degrees C
Storage Information 2-8 degrees C
In Vivo Use (Preclinical)
Is there an associated publication? No
Disease Area/Pathogen: Virus
Parent Organism: Severe acute respiratory syndrome-related coronavirus
Antigen: Recombinant protein
Immunization Route: IM
Readout: Immunogenicity (serology)
Host Species: Mouse-C57BL/6
Were PK/Toxicology studies conducted? No
Product Grade and Formulation(s)
Product Grade: Research-grade only
Formulation(s): Bedsidemixing
Bedside mixing with antigen possible? Yes
Also used in combination adjuvant-formulation? No
Clinical
Not evaluated in humans yet
EmT4™ is the same stabile, squalene-based emulsion in Em™, but additionally has an added TLR4 agonist component. Together they enhance immune responses to antigens and skew to a T<sub>H</sub>1 profile. Each 0.5 mL vial of EmT4™ contains 0.5 mL of 4% oil emulsion with 200 μg of TLR4 agonist.
Recently Viewed Items
You haven't viewed at any of the products yet.